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What is Regenerative Medicine?
Regenerative medicine is a fast-emerging branch of veterinary medicine in which the body’s own cells are used to heal and ultimately regenerate damaged tissues in acute and chronic conditions. At Taylor Animal of Parkville, we are using platelet rich plasma (PRP) to help our patients.
- Platelet Rich Plasma (PRP)
Platelet rich plasma is an autologous (self-derived) conditioned plasma that contains a high concentration of platelets. Platelets contain numerous growth factors that facilitate tissue repair and healing. These growth factors are contained in the alpha granule portion of the cell and are released from the platelet when it is activated (usually at an area of injury). A few examples of these growth factors are: Transforming Growth Factor β (TGF-β), Platelet Derived Growth Factor (PDGF), Insulin-like Growth Factor (IGF-1), Vascular Endothelial Growth Factor (VEGF), Epidermal Growth Factor (EGF) and Fibroblast Growth Factor (FGF). Roles of these growth factors range from vessel development and repair, to cellular recruitment and activation.
Indications For Use
Regenerative therapies like platelet rich plasma (PRP) can be used for a wide range of conditions including:
- Osteoarthritis
- Ligament Injuries
- Tendon Injuries
- Burn Wounds
- Open Wounds
- Bone Grafts
- Certain Spinal Conditions
How It Works:
Regenerative medicine helps the body utilize its own cells to stimulate recovery. Read below about how platelet rich plasma (PRP) and stem cell therapy work.
- Platelet Rich Plasma (PRP)
Platelet rich plasma contains numerous growth factors that facilitate tissue healing and repair. Growth factors are small proteins that are contained within a compartment inside the platelet called the alpha granule. When a platelet is exposed to an area of damage or to fibrinogen, it becomes activated and changes its shape so that the alpha granule releases its growth factors. These growth factors play an important role in tissue repair by promoting new vessel formation, enhancing cellular proliferation and promoting extracellular matrix formation.
System Validation
When it comes to choosing a PRP isolation system, the most important question to ask is: Is the system validated for use in Canine patients? There are numerous isolation systems available, but very few are specifically validated for use in dogs.
The Companion Regenerative Therapies (CRT) system has been specifically validated for use in canine patients. In a multicenter study, the CRT Pure PRP system was the only system that increased platelet concentration while significantly reducing the red blood cell and neutrophil concentrations.
Why is it Important to Reduce Neutrophils and Red Blood Cells (RBCs)?
Neutrophils:
- Multiple studies show that neutrophils increase concentrations of unwanted inflammatory mediators (IL-1β, TNF-α, IL-6, IL-8)
- Increase concentrations of neutrophils in PRP is positively correlated with an increased MMP-9 concentration, which leads to degradation of collagen and other extracellular matrix molecules.
Red Blood Cells:
- RBC’s damage cartilage and synovium directly via iron-catalyzed formation of Reactive Oxygen Species (ROS)
- RBC’s increase concentration of unwanted inflammatory mediators (IL-1 and TGF-α)
- PRP with high concentration of RBC’s caused significantly more synoviocyte death when compared to PRP preparations with lower RBC count
Call Us
We look forward to healing your pet! Schedule your appointment today.
We accept appointments within
24-48 hours.
(816) 441-3058
"Love them! The staff is great! Always attentive to my pups' needs."
- Tami Camlin
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